SLU-PP-332

SLU-PP-332 – Premium Research-Grade ERR Agonist

Distributed Worldwide by Gizem Peptides

SLU-PP-332 is a high-purity, research-use-only small molecule designed as a pan–Estrogen-Related Receptor (ERR) agonist, demonstrating activity across all three major ERR subtypes: ERRα, ERRβ, and ERRγ. This compound is widely used in advanced biochemical and metabolic research for exploring mitochondrial regulation, oxidative metabolism, and cellular energy homeostasis.

With its carefully characterized pharmacological profile, SLU-PP-332 provides researchers with a powerful tool to investigate how ERR signaling pathways influence energy production and metabolic adaptation in skeletal muscle and other high-energy-demand tissues.

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Mechanism of Action & Receptor Activity

SLU-PP-332 functions as a broad-spectrum agonist of the ERR nuclear receptor family, which plays a central role in regulating genes involved in mitochondrial biogenesis and oxidative phosphorylation.

Its receptor potency has been quantified through EC50 measurements:

• ERRα: EC50 = 98 nM (high affinity activation)
• ERRβ: EC50 = 230 nM (moderate affinity activation)
• ERRγ: EC50 = 430 nM (selective activation profile)

This activity profile highlights SLU-PP-332 as a balanced pan-ERR modulator, with strongest activity toward ERRα, a key regulator of mitochondrial density and oxidative energy metabolism in muscle tissue.

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Effects on Cellular Metabolism (Research Observations)

In experimental settings, SLU-PP-332 has been shown to:

• Enhance mitochondrial function in skeletal muscle cell lines
• Improve cellular respiration efficiency
• Upregulate pathways associated with oxidative metabolism
• Support increased energy utilization and metabolic gene expression

These properties make it particularly valuable for studying how ERR signaling contributes to cellular energy balance and metabolic flexibility.

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Research Applications

SLU-PP-332 is widely utilized in preclinical and laboratory research focused on:

• Metabolic disease modeling and pathway analysis
• Mitochondrial biogenesis and dysfunction studies
• Skeletal muscle energetics and performance biology
• Nuclear receptor signaling research (ERR family)
• Cellular respiration and oxidative phosphorylation experiments

Its consistent activity profile enables reproducible results in both in vitro and mechanistic biological studies.

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Quality, Supply & Global Distribution

Gizem Peptides supplies SLU-PP-332 as a high-purity research compound designed for laboratory and institutional use. We maintain strict quality control standards to ensure batch consistency, structural integrity, and analytical verification suitable for advanced scientific research.

We provide wholesale distribution worldwide, supporting:

• Research laboratories
• Biotechnology companies
• Academic institutions
• Pharmaceutical R&D organizations

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Important Notice

SLU-PP-332 is supplied strictly for research and laboratory use only. It is not intended for human consumption, diagnostic use, or therapeutic application. All handling should be performed by qualified professionals in controlled research environments.